Medical Management of Lower Urinary Tract Symptoms

[摘要] Lower urinary tract symptoms (LUTS) are a common complaint among aging men and are often caused by benign prostatic hyperplasia (BPH). A number of medical treatments for LUTS/BPH exist, such as α-blockers, 5α-reductase inhibitors, anticholinergics, phosphodiesterase type 5 (PDE5) inhibitors, and combination therapies. Agonist binding of the α1A-adrenergic receptor (AR), causing prostatic smooth muscle contraction, has been attributed to cause some LUTS. Therefore, medical therapy has aimed to block the α1A-AR and improve LUTS. Determining which therapy to choose must take into account individual patient factors as well as cost and patient choice.

[学科分类] 基础医学

[关键词] 5α-reductase inhibitors;α-Blockers;Anticholinergics;Benign prostatic hyperplasia;Combination therapy;Lower urinary tract symptoms;Phosphodiesterase type 5 inhibitors