The Use of Alpha-Blockers for the Treatment of Nephrolithiasis

[摘要] Medical expulsion therapy has been shown to be a useful adjunct to observation in the management of ureteral stones. Alpha-1-adrenergic receptor antagonists have been studied in this role. Alpha-1 receptors are located in the human ureter, especially the distal ureter. Alpha-blockers have been demonstrated to increase expulsion rates of distal ureteral stones, decrease time to expulsion, and decrease need for analgesia during stone passage. Alpha-blockers promote stone passage in patients receiving shock wave lithotripsy, and may be able to relieve ureteral stent-related symptoms. In the appropriate clinical scenario, the use of α-blockers is recommended in the conservative management of distal ureteral stones.

[学科分类] 基础医学

[关键词] Alpha-blockers;Ureteral stones;Kidney stones