The Treatment of Hormone-Refractory Prostate Cancer: Docetaxel and Beyond

[摘要] Two randomized clinical trials demonstrated a survival benefit of 20% to 24% with docetaxel-based therapy when compared with survival with mitoxantrone and prednisone after failure of androgen ablation therapy. These studies supported the approval of docetaxel-based therapy for the treatment of metastatic hormone-refractory prostate cancer by the US Food and Drug Administration in May 2005. Clinical trials in hormone-refractory prostate cancer are now focused on building on the survival improvement seen with docetaxel-based therapy. This article presents a summary of some of the more promising treatments and regimens for advanced prostate cancer.

[学科分类] 基础医学

[关键词] Prostate cancer;Androgen ablation;Prostate-specific antigen;Estramustine;Docetaxel;Endothelin receptor antagonist