Optimizing the Role of Hormonal Therapy in the Management of Prostate Cancer

[摘要] The era of androgen deprivation therapy (ADT) was ushered in by Huggins and Hodges in their 1941 publication reporting that both surgical castration (orchiectomy) and medical castration with diethylstilbestrol (DES) produced dramatic regression and palliation of advanced prostate cancer. Estrogen therapy was considered the more appealing of these options because patients generally preferred to avoid a surgical procedure, particularly one requiring removal of the testes. Subsequently, estrogen therapy with DES was shown to produce unacceptably high rates of cardiovascular toxicity and was withdrawn from the market, creating the need for a safer form of medical castration.

[学科分类] 基础医学