Sodium Bicarbonate to Reduce Contrast-Induced Nephropathy

[摘要] A significant number of urologic patients are evaluated with imaging studies in which iodinated contrast is administered intravenously. Contrast-induced nephropathy is a potential sequel of such studies. It is thought that free radical generation is a causative factor of this problem.1 The administration of N-acetylcysteine, the use of the iso-osmolar contrast agent iodixanol, and hemofiltration before and after contrast administration have been used to reduce renal dysfunction after contrast loads.2–4 Free radical generation occurs more readily in an acidic environment and is attenuated by higher extracellular pH. Merten and colleagues performed a randomized controlled trial to assess whether hydration with the administration of intravenous sodium bicarbonate before, during, and after contrast administration limits the risk of renal dysfunction.

[学科分类] 基础医学