Single Nucleotide Polymorphisms and Prostate Cancer Susceptibility

[摘要] According to twin studies, heritable factors account for a substantial fraction of prostate cancer risk.1 Until recently, linkage studies were primarily used to identify gene mutations that cosegregate in prostate cancer families. A notable example is the HPC1 gene on chromosome 1q24-25.2 Unfortunately, such gene mutations account for a small minority of familial prostate cancer cases, so investigation has continued for more prevalent genetic variants.

[学科分类] 基础医学