Prostate Cancer: Progression, Risk Reduction, and Future Options

[摘要] Prostate disease, either symptomatic benign prostatic hyperplasia (BPH) or cancer, is a significant health problem. The estimated prevalence of symptomatic BPH from community-based studies is 40% for men in their 70s, and histological evidence of BPH in autopsy studies is found in 60%–80% of men aged 60–69 years.1–3 Prostate cancer has been the most common visceral malignancy in U.S. men for more than 10 years. The estimated lifetime risk of disease is 16.6% for Caucasians and 18.1% for African Americans, with a lifetime risk of death of 3.5% and 4.3%, respectively.4 The prevention of either or both of these diseases could have a significant impact on the quality of life of a very large at-risk population. This supplement, based on a symposium presented at the 2002 Annual Meeting of the American Urological Association, summarizes the current state of scientific and clinical knowledge on the etiology and prevention of these diseases.

[学科分类] 基础医学