Blood cells: an historical account of the roles of purinergic signalling

[摘要] The involvement of purinergic signalling in the physiology of erythrocytes, platelets and leukocytes was recognised early. The release of ATP and the expression of purinoceptors and ectonucleotidases on erythrocytes in health and disease are reviewed. The release of ATP and ADP from platelets and the expression and roles of P1, P2Y₁, P2Y₁₂ and P2X1 receptors on platelets are described. P2Y₁ and P2X1 receptors mediate changes in platelet shape, while P2Y₁₂ receptors mediate platelet aggregation. The changes in the role of purinergic signalling in a variety of disease conditions are considered. The successful use of P2Y₁₂ receptor antagonists, such as clopidogrel and ticagrelor, for the treatment of thrombosis, myocardial infarction and stroke is discussed.

[学科分类] 分子生物学，细胞生物学和基因

[关键词] Clopidogrel