Evaluation of the Oculomedin gene in the etiology of primaryopen angle and exfoliative glaucoma

[摘要] Purpose: Glaucoma is a disease of the retinal ganglion cells leadingto reduction of peripheral vision. It is often associated with anincrease in intraocular pressure, leading to mechanical stress oftissues. The oculomedin gene is activated by such stretching and istherefore a candidate for causing glaucoma.Methods: The coding sequence and part of the promoter was screenedfor sequence variants in Swedish cohorts of primary open angle glaucoma,exfoliative glaucoma, and matched controls.Results: Only rare variants were detected in the patient material.Conclusions: There was no evidence that the oculomedin geneparticipates in the etiology of glaucoma.

[学科分类] 生物化学/生物物理