Exclusion of 14 candidate loci for primary open angle glaucoma inFinnish families

[摘要] Purpose: The aim of the present study was to examine the geneticbackground of primary open angle glaucoma (POAG) in the Finnishpopulation by analyzing previously reported candidate loci GLC1B on2cen-q13, GLCIC on 3q21-q24, GLC1D on 8q23, GLC1F on7q35-q36, as well as other candidate regions on chromosomes 2p14,2q33-34, 10p12-13, 14q11, 14q21-22, 17p13, 17q25, and 19q12-14. Inaddition, we analysed loci for the MYOC gene on 1q23-24 and theOPTN gene on 10p14-15.Methods: Eight Finnish families (92 family members; 27 individualswith POAG; 19 individuals with ocular hypertension or glaucomasuspicion) were genotyped using 35 microsatellite markers on thecandidate loci and analyzed for linkage.Results: No significant evidence for linkage was found in two pointand multipoint linkage analyses to the tested markers in the analyzedfamilies.Conclusions: Our results support further genetic heterogeneityunderlying POAG and encourage a search of novel genetic loci andpredisposing genes in order to understand the genetic mechanismsunderlying POAG.

[学科分类] 生物化学/生物物理