Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve

[摘要] Purpose: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls.Methods: Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues.Results: We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG).Conclusions: This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline.

[学科分类] 生物化学/生物物理