Effects of Anti Epileptic Drugs Phenytoin and Phenobarbital on Ossification Indices of Mouse Femur And Tibia And The Anti Teratogenic Effects of Folic Acid on the Reduction of Their Effects

[摘要] Introduction: Patients suffering from epilepsy have to take antiepileptic drugs forever. It has been suggestedthat epilepsy itself and antiepileptic drugs are teratogenic. All aspects of the abnormalities that are inducedby these drugs are unclear. Therefore, the objectives of this study were to determine the effects of tworoutine antiepileptic drugs on ossification. Besides, there was an attempt to decrease their teratogenic effectsby using folic acid.Materials and Methods: 81 female mice (BALB/c) were selected and divided into six groups. Pregnant micewere fed with phenytoin (45mg/kg), Phenobarbital (30mg/kg), phenytoin and folic acid (15

[学科分类] 药学、药理学、毒理学（综合）

[关键词] demosponge;spiculite;turbidite;Silesian Basin;Outer Carpathians;Cenomanian