Fatigue as a Residual Symptom of Depression

[摘要] It is well recognized that many patients with major depressive disorder (MDD) do not achieve a full response to antidepressant medications despite adequate dose and duration of the treatment. One of the most common residual symptoms of a partially resolved depression is fatigue. Broadly defined, symptoms of fatigue can affect physical, cognitive, and emotional function, impair school and work performance, disturb social and family relationships, and increase healthcare utilization. Furthermore, some of the medications we use to treat MDD can induce symptoms of fatigue as side effects. Given the importance and complexity of fatigue occurring in patients with MDD, I discussed this topic with Maurizio Fava MD, Slater Family Professor of Psychiatry at the Harvard Medical School. Dr. Fava is also Executive Vice Chair of the Department of Psychiatry, Executive Director of the MGH Clinical Trials Network and Institute (CTNI), and Director of the Depression Clinical and Research Program at the Massachusetts General Hospital, in Boston, Massachusetts.

[学科分类] 精神健康和精神病学