Design and evaluation of self-nanoemulsifying drug delivery systems(SNEDDS) for Gliclazide

[摘要] Self-nanoemulsifying drug delivery systems (SNEDDS) were developed with the objective toovercome problems associated with the delivery of Gliclazide, a poorly bioavailable, anti-diabetichaving pH dependant solubility. Solubility of Gliclazide in oily phases and surfactants weredetermined to identify components of SNEDDS. Various surfactants and co-surfactants werescreened for their ability to emulsify selected oily phases. Ternary phase diagrams wereconstructed to identify area of nanoemulsification for the selected systems. The influence ofGliclazide and pH of dilution medium on the phase behavior of selected system were assessed.The globule size of optimized Gliclazide SNEDDS in various dissolution media was determined tocheck the effect of pH on its behavior. The optimized Gliclazide SNEDDS needed surfactantcontent less than 55% and yielded nanoemulsion of mean globule size 146 nm, which was notaffected by the pH of dilution medium. The optimized SNEDDS released the Gliclazide drugcompletely within 20 min irrespective of the pH of dissolution medium.

[学科分类] 药理学