Formulation and development of Famotidine floating tablets forgastric irritation

[摘要] The purpose of the study was to prolong the gastric residence time of famotidine by designing itsfloating tablets and to study the influence of different polymers on its release rate. Threeformulations of famotidine containing varying concentrations of polymers were designed byoptimization. The floating matrix tablets of famotidine were prepared by direct compressionmethod. The prepared tablets were evaluated for physicochemical parameters such as hardness,floating properties (floating lag time, floating time and matrix integrity), and drug content. Thephysicochemical parameters of formulated tablets were found to be within normal range. Thefloating lag time of all the formulations was within the prescribed limit (54 Sec). All theformulations showed good matrix integrity and retarded the release of drug for 12 hours. Thedrug release from F-II was found to follow zero order kinetics. It was also found linear inHiguchi’s plot, which confirms that diffusion is one of the mechanisms of drug release.

[学科分类] 药理学