Formulation and Evaluation of Buccoadhesive Films of LosartanPotassium

[摘要] Buccoadhesive buccal delivery systems for losartan potassium in the form of buccal films weredeveloped and characterized for improving bioavailability. The films were formulated by solventcasting method using different bioadhesive polymers like HPMC, Eudragit RS100, EudragitRL100 and Ethylcellulose with glycerol as plasticizer. The films were characterized on the basisof their physical characteristics, bioadhesive performance and other parameters. In vitro studiesrevealed that release rate of losartan potassium was higher from films containing ratio of HPMCand Eudragit RL100 in proportion of 2:2. Drug diffusion from buccal films showed Peppasmodel kinetics and release mechanism was non-fickian. All the films exhibited sufficient in vitrobioadhesion strength. Promising formulation was further studied for temperature dependantstability studies. The results indicated that, therapeutic level of losartan potassium can beachieved using this buccoadhesive formulation.

[学科分类] 药理学