Formulation of Drug-Resin complex and evaluation of its molecular propertyand release kinetics

[摘要] The purpose of this research was to formulate tasteless complexes of Fexofenadin Hydrochloridewith Doshion P547 and to evaluate different factor affecting Drug-Resin Complexation wise,effect of batch and column process, complexation time, temperature, and pH on FexofenadinHydrochloride loading on Doshion P547 is reported. Drug resin complexes (DRC) werecharacterized by infrared spectroscopy, thermal analysis. Fexofenadin Hydrochloride releasefrom DRC is obtained at salivary and gastric pH. The efficient drug loading was evident in batchprocess using activated Doshion P547 with a drug-resin ratio of 1:3. Drug complexationenhanced with pH from 1.2 to 5, while temperature did not affect the complexation process.Infrared spectroscopy revealed complexation of –NH (drug) with Doshion P547. Drug releasefrom DRC in salivary pH was insufficient to impart bitter taste. Complete drug release wasobserved at gastric pH in 2 hours. Doshion P547 is inexpensive, and the simple technique iseffective for bitterness masking of Fexofenadin Hydrochloride.

[学科分类] 药理学