Synthesis, Characterization and Evaluation of Novel substitutedbenzo-indolylidene acetohydrazide Derivatives as Anti-MicrobialAgents

[摘要] A series of benzo-indolylidene acetohydrazides were synthesized by condensation of 2-chloro-N-[2-oxo-1,2-dihydro-3H-benzo[g]indol-3-ylidene]-acetohydrazide with various amines and testedfor their antibacterial activities against various Gram-positive and Gram-negative bacteria andantifungal activity against the fungus Candida albicans and yeast. The synthesized compounds6a-6f was characterized by spectral data (IR, NMR and mass) and elemental analysis. Allcompounds were screened for their antibacterial and antifungal activity by Cup-plate method(disc method). The Compounds 6e and 6f, showed considerable enhanced antibacterial activityagainst all microorganisms. Microbiological results indicated that the synthesized compoundspossessed a broad spectrum of activity against the tested microorganisms.

[学科分类] 药理学