Proniosomal Gel: A provesicular approach for transdermal drugdelivery

[摘要] Over the last few years a comprehensive research has been done over proniosomal gel as aprovesicular approach for transdermal drug delivery. However skin has a very tough diffusionbarrier that is lipid bilayer in the stratum corneum inhibiting penetration of drug moiety which israte limiting barrier for penetration of drugs. Vesicular systems (niosomes & liposomes) arepromising systems to cross this permeation barrier. They may act as vehicles or as permeationenhancer for bioactive materials to enhance their penetration via stratum corneum. But theirmajor drawback is their unstability, which can be overcome by utilizing provesicular approacheslike proniosomes. Proniosomes (gel) are semisolid liquid crystal products of nonionicsurfactants easily prepared by dissolving the surfactant in a minimal amount of an acceptablesolvent (ethanol) and the least amount of aqueous phase (water). Proniosomal gel offers a greatpotential to reduce the side effects of drugs and increased therapeutic effectiveness. Proniosomescan entrap both hydrophilic and hydrophobic drugs. In this review we have coveredproniosomal drug delivery along with preparation, formulation and evaluation parameters ofproniosomes as drug carrier.

[学科分类] 药理学