Rifampicin Proniosomes- An Approach to Improve the Stability ofNiosomes

[摘要] The aim of the work was to prepare a Rifampicin niosomal formulation and to compare theentrapment efficacy and release having Cholesterol and Myristyl alcohol as membranestabilizers and to convert the niosome formulation into proniosome for improved stability. Sixformulations of Rifampicin niosomes were prepared with three different surfactants by thin filmhydration method using cholesterol and myristyl alcohol as membrane stabilizers. The niosomalsuspensions were evaluated for size analysis, drug entrapment and invitro release.Lyophilization was also performed for niosomal formulation. Rifampicin proniosome wereprepared by thin film hydration method using mannitol as carrier with surfactant Span20. Theformulations of span 40 with myristyl alcohol and span 20 with cholesterol showed higherentrapment efficiency. Invitro drug release from span 20 formulations with cholesterol wasfound to be slower than with the formulation containing span 40 with myristyl alcohol. The studyproves that the membrane stabilizing activity of cholesterol shows the feasibility of storingniosomal suspension in the form of proniosomes for a longer duration.

[学科分类] 药理学