Formulation and Evaluation of Solid binary systems of an Antipsychotic Drugby Using a modified Carrier

[摘要] The aim of the study was to formulate and evaluate solid binary systems of the poorly watersolublenovel antipsychotic drug ziprasidone hydrochloride. The solid binary systems wereprepared by using a new carrier (modified starch such as starch phosphate) for improving thedissolution properties. Starch phosphate was prepared by a reported method. The solid binarysystems were prepared by kneading method in different drug to carrier molar ratios (1:1, 1:3,1:9 and 1:19). Evaluation of the solid binary system was performed using dissolution studies,Differential thermal analysis, Infrared Spectroscopy and X-ray powder diffraction studies. Allthe solid binary systems showed dissolution improvement when compare to pure drug andphysical mixture to varying degrees, binary systems prepared by kneading method in 1:9 drug tocarrier ratio exhibited the highest drug release. Mathematical modeling of in vitro dissolutiondata indicated the best fitting with Korsemeyer-Peppas model and the drug release kineticsprimarily as Fickian diffusion.

[学科分类] 药理学