Formulation and in vitro evaluation of sustained releasemicrospheres of Metoprolol Tartrate Loaded Eudragit-RS100

[摘要] The objective of the present study was to microencapsulate the Anti-Hypertensive drug(treatment of several disease of Cardio Vascular System, especially Hypertension.) MetoprololTartarte to provide Sustain Release and maintain constant the plasma drug concentration andreduce the frequent administration and improve the Patient compliance, unwanted side effectsand Dose dumping. Metoprolol was microencapsulated with Eudragit-RS100 using solventevaporation techniques. The effect of different 6 Formulation variables including the drugpolymer ratio. Metoprolol Microspheres was subjected to micrometritic properties includingAngle of Repose, Bulk density, Carr’s index, Haugner’s ratio and Particle size determination.Metoprolol Microspheres was subjected to Drug Loading, invitro drug release as well as forScanning electron microscope and kinetic drug release.

[学科分类] 药理学