Design, Synthesis, Analgesic and Anti-Inflammatory Activity of Somenovel Chalconesemicarbazone derivatives

[摘要] In the present study we have designed a new pharmacophore ‘Chalconesemicarbazone’ bypharmacophore hybridization approach of drug design. A series of novel‘chalconylsemicarbazide’ derivatives was synthesized. The synthesized compounds were evaluatedfor their analgesic and anti-inflammatory activities. Most of the compounds were found to bemore or comparable potent than the reference standard drugs. Based on the pharmacologicalscreening results 1-(1,5-diphenylpenta-2,4-dienylidene)-4-(2-nitrophenyl) semicarbazide (15)was the most active lead compound.

[学科分类] 药理学