Formulation and evaluation of transdermal patches of curcumin

[摘要] An attempt was made to formulate and evaluate the curcumin transdermal drug delivery system.Preformulation studies on the drug curcumin were done which included description, solubilityand compatibility studies. The transdermal patches were made which were of matrix diffusioncontrol system. Solvent casting technique was used to prepare the transdermal patches. Threeformulations were made with 20mg of curcumin and by using polymers namely hydoxy propylmethyl cellulose, ethyl cellulose at various ratios and the yield was noted. Curcumin wasphysically examined for color and odour. Solubility was determined in water, phosphate bufferpH -7.4, Ethanol, DMSO and Tetra hydro furan. Interaction of drug and polymer was confirmedby UV – Visible interaction and FTIR studies. Based on this further evaluation was carriedout.Invitro drug diffusion stuy was also carried out using modified Franz diffusion cell.Transdermal patches were evaluated for the weight, thickness, percentage moisture uptake,percentage flatness, folding endurance, water vapor transmission rate, and in-vitro releasestudies. This was done for three formulations F1, F2, F3. It was found that formulation F1showed the best compatibility on the basis of all tests performed.

[学科分类] 药理学