pH dependent, colon specific, delivery of Ornidazole andCiprofloxacin Hydrochloride in stomach

[摘要] This study was carried out to develop an oral colon specific, tablet to achieve site specificrelease of ornidazole and ciprofloxacin hydrochloride. The basic design consists of coating ofornidazole with eudragit to form microgranules and compressing the ciprofloxacin hydrchloridepowder into a tablet to release the ciprofloxacin hydrochloride in the stomach and finally withfilm coating for stability and esthetic appeal. The ornidazole was enteric coated, so that thevariability in gastric emptying time can be overcome and a colon-specific release can beachieved. The ornidazole microgranules were prepared with Eudragit®L-100, by varying drugto polymer ratio and evaluated for the particle size, drug content and in vitro release profile andfrom the obtained results; one better formulation was selected for further fabrication of tablet.The aim behind developing this formulation was that when any patient suffers from amebiasis,can be treated with conventional ornidazole tablet for instant release but after that the organismresides at the lower GIT(colon) in the dormant phase and many times relapse of the conditionoccur with the patient. Thus it can be avoided by targeting the drug at the colon after the initialtreatment.

[学科分类] 药理学