Development and Evaluation of Press Coated Tablets forChronopharmaceutical Drug Delivery using Gellable andPermeable Polymers

[摘要] The role of chronotherapeutics in hypertension management is based on the recognition thatblood pressure does not remain constant throughout the day. Instead, it tends to be higher inthe early morning hours and lower in the evening hours. The main objective of the presentstudies reported here was to investigate whether compression coating could be used toproduce tablets providing maximum in-vitro drug release 6 to 8 hours after an evening dosetaken at approximately 10:00 pm. The basic idea behind the dosage form development is toinvestigate effect of coating design on lag time and drug release from directly compressedtime-controlled release tablet. The aim of the present study was to design time controlledtablet of Diltiazem hydrochloride, as Chronopharmaceutical drug delivery system bycompression coating. Formulation design involves coating polymer blend ratio (100:0,75:25, 50:50, 25:75, 0:100 w/w) of Klucel HF, Klucel HXF and Eudragit RSPO which wereexploited for their pulsatile drug release ability. The effect of different weight ratio ofcombination of permeable polymers and gellable polymer, different particle size of gellablepolymer in outer shell polymers blend were studied on the drug release behavior of the timecontrolled tablet formulation. Coating materials blend were evaluated for micromeriticproperties like flow properties, compressibility index, Hausner’s ratio and also evaluated thetablet for hardness, thickness, friability, weight variation, water uptake studies. The obtainedresults showed the capability of the system in delaying drug release for a programmableperiod of time to attain drug release 6 to 8 hours after an evening dose taken atapproximately 10:00 pm according to a time-dependent approach.

[学科分类] 药理学