Formulation and Evaluation of Different Polymer based PeriodontalFilm of Ofloxacin

[摘要] In present investigation periodontal films of ofloxacin was formulated using different polymers.Simple casting method was used to prepared films of chitosan, carbopol 934, polyvinyl pyrrolidineK30 and hydroxy propyl methyl cellulose K4M. In different formulations glycerine was used asplasticizer. Prepared films were evaluated for thickness uniformity, weight uniformity, tensilestrength, folding endurance, moisture loss, content uniformity and drug release. Results obtainedfrom different studies were found within acceptable limits. Film containing chitosan showedmaximum tensile strength over other batches. Films prepared using Carbopol 934 showedmaximum drug release (98.35) over a long period of time. The findings of the results easily predictthe fact that chitosan, carbopol 934, polyvinyl pyrrolidone K30 and hydroxy propyl methylcellulose K4M can be used to prepare film for the treatment of peridontal disease.

[学科分类] 药理学