In vitro evaluation of polymeric beads of riboflavin formulated atdifferent cross-linking time

[摘要] Sodium alginate beads were evaluated as sustained release vehicles for the delivery ofRiboflavin. It has been shown that the structure of the cross-linked calcium alginate network is ofprimary importance in the retention and/or release of the Riboflavin. The Riboflavin beadformulations were prepared by dispersing Riboflavin together with a mixture of sodiumalginate and plasticizer solution and then dripping the dispersion into a solution of 5% (w/v)calcium chloride for different time of cross linking. Prepared beads were evaluated for Particlesize, Flow property, Drug entrapment efficiency and in-vitro drug release. The formulationsshowed the particle size and angle of repose within acceptable range having good flow propertybut the beads formed by high cross linking time demonstrated nearly same particle size andshowed poor flow property as compared with other formulations. Drug entrapment efficacy ofall formulations was in the range of 55.76 - 74.21% and entrapment efficacy of beads decreaseswith increase the cross linking time. Riboflavin in-vitro release from beads was studied. TheBeads prepared by maximum 15 minutes cross linking time shows 77% drug release. The valuesof coefficient correlation were calculated and drug release was found to follow Higuchi matrixorder release.

[学科分类] 药理学