Formulation and evaluation of acyclovir microcapsules usingbiodegradable and non-biodegradable polymers

[摘要] To formulate and evaluate Acyclovir microcapsules using biodegradable and non-biodegradablepolymers namely egg albumin, guar gum and ethyl cellulose and its invitro evaluation. TheAcyclovir microcapsules were prepared using different concentrations of egg albumin, guar gumand ethyl cellulose. The microcapsules were prepared using solvent diffusion method and heatcoagulation method. The microcapsules were then studied for entrapment efficiency at twodifferent stirring speeds, drug polymer compatibility and surface morphology. The invitrorelease study was also done. Further kinetic modeling was employed to find out the releasemechanisms. Acyclovir loaded microcapsules formulated with guar gum showed an entrapmentefficiency of 92.97%, with ethyl cellulose 91.96% and the entrapment efficiency with eggalbumin was 90.61%. The SEM showed that the microcapsules were free flowing, nonaggregated and spherical between 700-1000 μm in diameter. The surface was wavy inmicrocapsule formulated with guar gum, porous in microcapsules using ethyl cellulose andsmooth in the case of microcapsules formulated with egg albumin. The FTIR spectrum showedthat there is no interaction between the polymer and the drug. The invitro release study wasfound to be the best in the case of acyclovir microcapsules formulated with guar gum. The rate ofdrug release follows a time dependent process based on fickian diffusion and korsemeyerpeppasmodel that the drug release is by diffusion and by erosion. The acyclovir microcapsulesusing various polymers can be used as oral controlled delivery of the antiviral drug acyclovir.

[学科分类] 药理学