Synthesis and biological activity of 3-(2-(5-Benzoyl-1h-Benzo[d] Imidazol-1-Yl) Acetyl)-5-Benzylidene-2-Alkylthiazolidin-4-One

[摘要] 2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) acetohydrazide (3) undergoes facile condensation witharomatic aldehydes to afford the corresponding 2-(5-benzoyl-1H-benzo[d]imidazol-1-yl)-N'-alkylidene aceto hydrazide (4a-h) in good yields. Cyclocondensation of compounds (4a-h) withthioglycolic acid yields 3-(2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) acetyl)-2-alkylthiazolidin-4-one (5a-h). These (5a-h) compounds are for the reacted with benzaldehyde in the presence ofsodium ethanolate affords, giving 3-(2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) acetyl)-5-benzylidene-2-alkylthiazolidin-4-one (6a-h). The structures of these compounds were establishedon the basis of analytical and spectral data. All the newly synthesized compounds were evaluatedfor their antibacterial and antifungal activities.

[学科分类] 药理学