Electronic evaluation by sensing device

[摘要] Many active pharmaceutical ingredients usually associated with bitterness, can impart anunpleasant taste or odor. To produce a desirable oral drug product, especially if destined forpediatric use, development efforts focus on masking the unpleasant taste or odor, often by addingflavoring or sweetening agents to the formulation. The formulations organoleptic propertiestaste, odor, mouth-feel and appearance are of considerable importance in differentiatingproducts in the market and can ultimately determine the success of a product. Organolepticanalysis of such prototype products is commonly performed by human taste panels. However, inan effort to eliminate human testing due to the safety risks and since it is time-consuming andexpensive, alternative analytical means are being sought. The electronic tongue or electronicnose is such a system for automatic analysis and recognition of liquids or gases, includingarrays of non-specific sensors, data collectors and data analysis tools. Electronic tongues areused for liquid samples analysis, whereas electronic noses for gases. The result can be theidentification of the sample, an estimation of its concentration or its characteristic properties.The novel electronic tongue technology is being utilized by the food/beverage andpharmaceutical industries to evaluate product taste characteristics. The electronic-nose devicemay provide testing of odors and also provide physicians with a quicker and more accuratediagnostic tool for a number of diseases. Also it can be used for detection and identification ofcertain chemical compounds in exhaled air and excreted urine or body fluids related to specificmetabolic conditions, certain skin diseases, or bacterial infections.

[学科分类] 药理学