Evaluation of wound healing activity of Ichnocarpus frutescens root

[摘要] The methanol extract of Ichnocarpus frutescens R. Br (Apocynaceae) roots were investigated forthe evaluation of their wound healing potential on different experimental models of wounds inrats. The methanol extract of roots (MEIF), in the form of an ointment with two differentconcentrations (1 % and 2 % w/w ointment of root extract in simple ointment base) wasevaluated for wound healing potential in an excision wound model and an incision wound modelin rats. Both concentrations of the methanol extract ointment showed significant responses inboth the wound types tested when compared with the control group. The effect produced by theextract ointment, in terms of wound contracting ability, wound closure time, regeneration oftissues at wound site, tensile strength of the wound and histopathological characteristics werecomparable to those of a standard drug framycetin sulphate cream.

[学科分类] 药理学