Floating Microspheres: An Innovative Approach for GastricRetention

[摘要] Various scientific and technological attempts have been made in the development ofgastroretentive dosage forms to overcome several physiological adversities, such as shortgastric residence time, unpredictable gastric emptying time etc. These dosage forms can beretained in the stomach for prolonged period of time in a predetermined manner.Gastroretentive drug delivery technology is one of the promising approach for enhancing thebioavailability and controlled delivery of drugs that exhibit narrow absorption window. Inpursuit of this endeavour, different novel strategies have been undertaken for the designing ofseveral gastroretentive drug delivery systems including floating microspheres. Thismanuscript highlights various developmental approaches, characterization aspects, potentialdrug candidates along with diverse advantages and applications of floating microspheres.Numerous significant research findings in the vistas of these multiparticulates have also beendescribed.

[学科分类] 药理学