Pharmaceutical Characterization of Cassia tora of Seed Mucilage inTablet Formulations

[摘要] Cassia tora (Cassia obstusifolia L) is a common herbaceous annual occurring as a weedthroughout India and belongs to the family of Caesalpiniaceae. Seeds of plant contain glucomannosehence attempt to evaluate the seeds for suitability as tablet binder is considered and thepresent investigation repots the isolation of mucilage of Cassia tora seed. The DSC and FTIRthermograms of drug and gum indicated no chemical interaction. Phytochemical characteristicsof mucilage such as carbohydrate, protein, fat and flavanoids etc. were studied. Physiochemicalcharacteristics of mucilage such as solubility, swelling index, loss on drying, viscosity, hydrationcapacity, powder porosity, microbiological properties and pH were studied. The mucilage wasevaluated for its granulating and binding properties in compressed tablet using Zidovudine asmodel drug. Mucilage was used in four different concentrations i.e. 2.0, 4.0, 6.0 and 8.0% w/v.The granules were prepared by wet granulation process. The prepared granules were evaluatedfor percentage of fines, average particle size, compressibility index and flow properties. Theproperties were compared with Guar gum which was used as standard binder at 8.0% w/vconcentration. The tablet were prepared and evaluated for content uniformity, hardness,friability, disintegration time and in vitro dissolution profile. The tablets had goodphysiochemical properties and the drug release was more than 85% within 4 hour. It wasobserved that increasing the concentration of mucilage increases hardness and decreases thedisintegration time. All the formulations (F1, F2, F3, F4 and F5) were subjected to stabilitystudies for three months at 25°C/60% RH, 30°C/65% RH and 40°C/75% RH as per ICHguidelines all four formulation showed stability with respect to release pattern and otherparameters which confirm the use of mucilage as excipient.

[学科分类] 药理学