Isolation and Characterization of Mucilage from Leaves of CinnamomumTamala Nees and Evaluation of Binding Property

[摘要] In the present study the mucilage obtained from bay leaves [cinnamomum tamala Nees(lauraceae)] was used as binder for the formulation of paracetamol tablets. The physicochemicalcharacterization of mucilage was done and the % swelling capacity of mucilage was found to be33.2%. Mucilage was also characterized by FTIR spectroscopy as well as qualitativephytochemical screening. Mucilage showed the presence of tannins and sugars. Five batches ofparacetamol tablets were prepared using three different concentrations (5, 10 & 15%) ofmucilage, PVP & starch as binder. From in-vitro release data it was observed that bay leavesmucilage posses good binding property similar to commercial pharmaceutical binders in theconcentration range between 10 to 15%. Tablets were also evaluated for hardness and friabilityand the friability values for all the tablets was found to be less than 1% and thus showing goodbinding property.

[学科分类] 药理学