Antifungal Potential of 1,2-4Triazole Derivatives and Therapeutic Efficacy of Tinea Corporis in Albino Rats

[摘要] New triazole 6-substituted-2[4’-(substituted phenyl-5’-thioxo)-1,2,4-triazol-3-yl}-methyl]- 2,3,4,5-tetrahydropyridazine-3-one derivatives possessing antifungal activity have been developed to meet the rising incidence of invasive fungal infections and the emergence of fungal resistance. The therapeutic efficacy of novel triazole derivatives for albino rat models with Trichophyton rubrum infection was investigated. Animals with developing infection were divided into five groups. The results show a marked decrease in the fungal burden on the skin. Hence, these novel triazole derivatives can be considered a promising candidate as a new antidermatophytic agent for topical use.

[学科分类] 药理学