Evaluation of acute toxicity for Abutilon indicum

[摘要] The present study investigated the acute toxicity of Abutilon indicum plant material in Swiss mice. The plant material was administered orally at dose ranging from 2gm to 10gm/Kg body weight as well as 10g/Kg body weight plant material as well as 10ml/Kg juice of fresh leaves and the animals were observed continuously for the first 4 hours for any behavior changes and they were then kept under observation up to 14 days after drug administration to find out the mortality. From the results it is concluded that Abutilon indicum plant material at doses of 10 g/kg as well as 10 ml/Kg is nontoxic since no marked changes in behavioral, food and water intake were observed. The Abutilon indicum plant material was found to be safe. No lethality or adverse toxic signs were seen during the experimental period and during 14 days observation period. No delayed toxic signs were noted in all experimental groups. These findings suggest that the Abutilon indicum could be relatively safe when administered orally in Swiss mice.

[学科分类] 药理学