Synthesis and antibacterial activity of 5-chloro-N-cyclohexyl- 6-thiosubstituted-nicotinamide derivatives

[摘要] A new route for the synthesis of 5-chloro-N-cyclohexyl-6-thio substituted-nicotinamide derivatives is reported. The antibacterial activity of all the synthesized compounds (4a-h) has been performed against gram positive and gram-negative bacteria. The compound 4c has found excellent antibacterial activity. The newly synthesized compounds are characterized by spectral data.

[学科分类] 药理学