Correlation studies between dissolution and thermal rate constants of Rabeprazole sodium drug and their tablets

[摘要] The thermal profile of rabeprazole sodium drug and tablets A, B and C were studied by isothermal thermogravimetry (TG) at different temperatures i.e. 120, 140, 160, 180 and 200 0C over 200 minutes under nitrogen atmosphere. The thermal data was used to calculate order of reaction and rate constant (kT). The dissolution profile was studied according to Indian Pharmacopeia and dissolution rate constant (kD) was calculated using Kitazawa equation. The rate constant kT and kD were correlated and were found to be complying a linear function, with correlation coefficient value close to 1 and follow the same order i.e. tablet A > tablet C > tablet B > rabeprazole drug.

[学科分类] 药理学