Novel Approach in Designing and In-Vitro evaluation of Mouth Dissolving Tablets of Metoclopramide Hydrochloride

[摘要] The purpose of the present work was to design Mouth dissolving tablets of Metoclopramide Hydrochloride by incorporating clove oil, which acts as flavoring and local anesthetic agent on the surface of the taste buds. Additionally Stevia leaf Powder was incorporated as sweetening agent which is 400 times sweeter than Sucrose. The tablets were prepared by direct compression technique. The formulated tablets were evaluated for Pre formulation and post formulation parameters and they were found to be satisfactory. Direct compression method was employed for making mouth dissolving tablets. The formulated mouth dissolving tablets possessed good drug releasing property, good mouth feel and improved drug availability with better patient compliance.

[学科分类] 药理学