Nanosuspensions: Ideal Approach for the Drug Delivery of Poorly Water Soluble Drugs

[摘要] Most of the drugs available to treat diseases are lipophilic in nature and challenging researchers to formulate them for a better bioavailablity. Out of all the approaches available nanosuspensions makes its way forward leading all other methods like cocrystals, microemulsions, liposomes etc. considering the advantages of nanosuspensions many attempts have been made to deliver poorly water soluble drugs as nanosuspensions prepared by adopting various methods. In this review, preparation methods, advantages of such methods, characterization of nanosuspensions, considerations and their applications have been reviewed hoping to make easy the future research in this area. Apart from the advancements till now, it scopes for further investigations in terms of pharmacokinetic and pharmacological correlations, invivo bioavailability studies and integration of physical chemistry, bio-informatics and biochemistry to study properties of nanosuspensions in detail.

[学科分类] 药理学