Formulation and evaluation of effervescent floating tablet of levofloxacin

[摘要] Levofloxacin effervescent sustained release tablets were developed in eight different formulations (F1 to F8) by employing different grades of polymers and effervescent agents such as sodium bicarbonate and citric acid. The formulations were evaluated for various physical parameters, dissolution parameters and drug released mechanisms. F8 formulation showed maximum floating time of 12 hours and gave slow and maximum drug release of Levofloxacin spread over 12 hours and whereas Levofloxacin released from marketed tablet was rapid and maximum within 8 hours.

[学科分类] 药理学