Formulation and evaluation of lamivudine enclosed alginate microbeads

[摘要] The objective of the present study was to prepare and evaluate microbeads for the controlled release of lamivudine from the prepared microbeads using different polymers. The microbeads were prepared by ionic gelation method. The prepared microbeads were characterized for FTIR, scanning electron microscopy (SEM), the percentage drug content, entrapment efficiency, and in vitro dissolution studies. Accelerated stability studies were also carried out for the formulations. The microbeads were spherical in shape and free flowing. The entrapment efficiency was varying from 76 to 86%. The release of drug from the microbeads was extended up to 8 to 12 hours. FTIR studies showed the stable character of lamivudine in the microbeads. SEM studies revealed that the microbeads were porous in nature. The release kinetics studies revealed that the prepared microbeads were best fitted to the zero order for all eight formulations and peppa’s model. The release kinetics data and characterization studies indicated that the drug release from microbeads was diffusion – controlled and the microbeads were stable in nature.

[学科分类] 药理学