Racemethionine Hepatoprotective Activity against Rifampicin Induced Hepatotoxicity in Albino Rats

[摘要] The current investigation was aimed to study the minimization of the effect of Rifampicin induced hepatotoxicity by the use of Racemethionine molecule which is an anti dote for paracetamol over dosage in humans. Racemethionine, a drug used for the treatment of toxic effects of paracetamol, was studied for its hepatoprotective activity against anti tubercular drug (Rifampicin) induced hepatotoxicity in wistar albino rats. The serum samples collected were estimated for various biochemical parameters. Racemethionine showed normalization of bio chemical parameters like serum glutamyl oxaloacetate transaminase (ASAT), serum glutamyl pyruvate transaminase (ALAT), alkaline phosphatase (ALP). Total cholesterol (TC) levels were found to be slightly raised in the Racemethionine treated group as compared to the anti tubercular drug treated group. The results indicated that Racemethionine showed to be a more potent hepatoprotective drug against Rifampicin induced hepatic injury in experimental animals. Hence racemethionine could be used for hepatoprotective study models in albino rats indicated by its reduction ability of ASAT, ALAT, ALP and TC in serum.

[学科分类] 药理学