Novel Approach in Designing of Mouth Dissolving Tablets for Bitter Drugs: Taking Clozapine as Model Drug

[摘要] The main merits of mouth dissolving tablets are faster onset of action, elegance, ease of administration, manufacturing, storage and transport. A novel attempt has been made to designing mouth dissolving tablets of Clozapine by the inclusion of clove oil as flavoring agent which also has local anesthetic action on taste buds of tongue. Additionally Stevia leaf powder was included as sweetener which has 400 times sweeter than Sucrose. The mouth dissolving tablets were prepared by direct compression technique. The formulated mouth dissolving tablets were evaluated for Pre compression and post compression parameters which were found to be satisfactory. The formulated mouth dissolving tablets possessed good drug release property, good mouth feel and improved bioavailability with better patient compliance.

[学科分类] 药理学