Design, development and optimization of famotidine gastroretentivedrug delivery system

[摘要] Famotidine (FMT) gastroretentive (GR) controlled release system was formulated to increase gastric residence time leading to improved drug bioavailability. Novel combinations of carbopol 940 P, Sodium Alginate, Guar Gum and Kollidon SR were selected for the present study. Floating lag time (Flag) and diffusion exponent as dependent variables revealed that the amount of carbopol 940 P, Sodium Alginate, Guar Gum and Kollidon SR have a significant effect (p < 0.05) on famotidine release and Flag. FMTGR tablets were prepared and evaluated for mass, thickness, hardness, friability, drug content and floating property. Tablets were studied for dissolution for 12 h and exhibited controlled release of FMT with floating for 12 h. The release profile of the optimized batch F2 (carbopol 940 P Sodium Alginate) and F6 (carbopol 940 P, Kollidon SR) fitted zero- -order kinetics.

[学科分类] 药理学