Dissolution profile of ketoprofen cyclodextrin complex

[摘要] Ketoprofen, 3-benzoyl-α-methylbenzeneacetic acid, is one type of non-steroidal antinflammatory drug and a weak acid poorly soluble in water. The effect of complexation Ketoprofen, a poorly water soluble non-steroidal anti-inflammatory drug (NSAID) with Cyclodextrins showed significant increase in dissolution profile with comparison a pure drug. Inclusion complexes were prepared by various methodologies i.e. co-precipitation, kneading etc, in molar ratio 1:1, 1:2, 1:3.

[学科分类] 药理学