Antidiabetic and antioxidant activity of Limonia acidissima linn. in alloxan induced rats.

[摘要] The present work is carried out to study the effect of Limonia acidissima.Linn (Rutaceae) on blood glucose levels and antioxidant enzymes levels in Alloxan induced diabetic rats. Alloxan (120 mg/kg, i.p) induced diabetic rats were treated with Limonia acidissima methanolic extract at a dose levels of 200 and 400 mg/kg for 21 days. Glucose level was measured in blood serum and antioxidant enzymes levels viz. Superoxide dismutase (SOD), Catalase (CAT) and Lipid Per oxidation (LPO) were measured in pancreatic homogenate, methanolic extract of fruit pulp of Limonia acidissima.Linn significantly (P<0.01) lowered the Alloxan induced hyperglycemia. It also produced a significant (P<0.01) decrease in peroxidation products viz. MDA in blood serum. The activity of antioxidant enzymes such as SOD, CAT was found to be higher in the blood serum of diabetic animals treated with the Limonia acidissima extract. This confirms the antihyperglycemic and antioxidant activities of Limonia acidissima in Alloxan induced diabetic rats.

[学科分类] 药理学