Antioxidant and Anti-inflammatory activities of Mitragyna parvifolia leaves extract

[摘要] Ethanolic leaves extract of Mitragyna parvifolia was screened for anti-inflammatory activity using Carrageenan-induced paw edema at various doses (100, 250 and 500 mg/kg) and the results were compared with standard drug Diclofenac sodium (50 mg/kg). It showed significant activity at 250 and 500 mg/kg (p < 0.01). The extract was also screened for antioxidant and free radical scavenging effects at various concentrations (100, 300 and 500 μg/ml) by reducing power assay, superoxide radical and DPPH free radical scavenging method. All these antioxidant activities were concentration dependent which were compared with standard antioxidants such as BHA and ascorbic acid. The highest antioxidant activity of M. parvifolia leaves extract was observed at a concentration of 500μg/ml.

[学科分类] 药理学