Development and evaluation of aceclofenac transdermal patches with different permeation enhancers

[摘要] This research work was an attempt to formulate and evaluate matrix-type transdermal therapeutic system containing Aceclofenac with different permeation enhancers (in different 3 ratios) by the solvent evaporation technique and explores the effect of permeation enhancers on the in vitro permeability of aceclofenac across excised goat skin. Matrix transdermal patches were prepared by using hydroxyl propyl methyl cellulose (HPMC) by incorporating dibutyl phthalate incorporated as plasticizer and oleic acid, peppermint oil and iso-propyl myristrate (IPM) as permeation enhancers in different 3 ratios 2%, 4% and 6% v/v in whole formula. Permeation studies were performed using modified Franz diffusion cell. All the patches were uniform with respect to physiochemical evaluation. The in-vitro permeation study indicate that formulation ATP-3(6% v/v oleic acid) showed maximum release of 74.513% in 12 hrs emerging to be ideal formulation. The developed transdermal patches increase the efficacy of Aceclofenac for the therapy of arthritis and other pain.

[学科分类] 药理学